A Study to Test Obrixtamig in Combination With Pumitamig in People With Advanced Small Cell Lung Cancer (Dareon®-Rosetta35)

This study is open to adults with extensive-stage small cell lung cancer. The purpose of this study is to find out how well people with this type of cancer tolerate taking study medicines called obrixtamig and pumitamig. Another purpose is to check whether the combination study treatment can make tumours shrink. Obrixtamig and pumitamig are being developed to help the immune system fight cancer. Participants are put into 2 groups. One group gets obrixtamig and pumitamig. The other group gets obrixtamig and pumitamig with standard chemotherapy (carboplatin and etoposide). All study treatments

Trial Details

NCT ID
NCT07843940
Phase
PHASE1 / PHASE2
Sponsor
Boehringer Ingelheim
Status
RECRUITING
Cancer Type
Lung Cancer
Interventions
  • Obrixtamig
  • Pumitamig
  • Carboplatin
  • Etoposide
Locations (sample)
  • Miami, Florida, United States|25.77427,-80.19366
  • Boston, Massachusetts, United States|42.35843,-71.05977
  • East Brunswick, New Jersey, United States|40.42788,-74.41598
  • New York, New York, United States|40.71427,-74.00597
  • Nashville, Tennessee, United States|36.16589,-86.78444

Key Eligibility Criteria

  • Signed and dated written informed consent in accordance with ICH-GCP and local legislation prior to any trial-specific procedures, sampling, or ana…
  • Male or female participants ≥18 years old and at least at the legal age of consent in countries where it is greater than 18 years at the time of si…
  • Willing and able to comply with scheduled visits, treatment schedule, the planned trial assessments, laboratory tests, restrictions regarding prohi…
  • Histologically or cytologically confirmed Extensive Stage Small Cell Lung Carcinoma (ES-SCLC) \[using the AJCC (American Joint Committee on Cancer)…

For full eligibility, visit ClinicalTrials.gov.

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