A Clinical Trial of Raludotatug Deruxtecan (R-DXd) With or Without Bevacizumab in Participants With Ovarian Cancer Who Have Progressed During Treatment With PARP-inhibitors Treatment on First Line Maintenance (MK-5909-008/ENGOT-ov107/GOG-3142 / REJOICE-Ovarian05)

Researchers are looking for new ways to treat advanced, high-grade ovarian cancer (OC). Advanced means the cancer has spread to other parts of the body (metastatic) and may not be removed with surgery. High-grade means the cancer cells grow and spread quickly. This trial includes types of OC that started in cells that cover the ovaries, in the lining of the belly, or in the fallopian tubes. The usual treatment for high-grade OC may include one or both of these: * Chemotherapy, which is a treatment that uses medicine to destroy cancer cells or stop them from growing. * Bevacizumab, which is a

Trial Details

NCT ID
NCT07743164
Phase
PHASE3
Sponsor
Merck Sharp & Dohme LLC
Status
RECRUITING
Cancer Type
High-Grade Serous Ovarian Cancer
Interventions
  • R-DXd
  • Bevacizumab
  • Carboplatin
  • Paclitaxel
  • Gemcitabine
  • Pegylated liposomal doxorubicin (PLD)
Locations (sample)
  • Fountain Valley, California, United States|33.70918,-117.95367
  • Orlando, Florida, United States|28.53834,-81.37924
  • Fort Worth, Texas, United States|32.72541,-97.32085
  • Jerusalem, Israel|31.76904,35.21633
  • Tel Aviv, Israel|32.08088,34.78057

Key Eligibility Criteria

  • Has a histologically or cytologically documented advanced high-grade serous or high-grade endometrioid epithelial ovarian, primary peritoneal, or f…
  • Has received 1 line of platinum-based therapy with a minimum of 4 cycles of platinum-doublet chemotherapy and have platinum-sensitive disease.
  • Has received a poly (ADP-ribose) polymerase inhibitor (PARPi) as maintenance treatment after the first line platinum-based chemotherapy course and …
  • Has an Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1 assessed within 7 days before randomization.

For full eligibility, visit ClinicalTrials.gov.

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