Global, Multicenter Study of AMT-116 Versus Investigator's Choice in Participants With Advanced or Metastatic Non-squamous EGFR-Wildtype Non-Small Cell Lung Cancer (NSCLC) With Progression on or After Platinum-Based Chemotherapy and Anti-PD-1/PD-L1 Immunotherapy

This clinical trial consists of two parts: phase 2 and phase 3. The goal of phase 2 of this clinical trial is to compare which dose level of AMT-116 works better to treat advanced or metastatic non-squamous EGFR-Wildtype non-small cell lung cancer (NSCLC) in adults. It will also learn about the safety of AMT-116. The main questions it aims to answer are: * Which level of AMT-116 works better to treat advanced or metastatic non-squamous EGFR-Wildtype NSCLC? * What medical problems do participants have when taking AMT-116? The goal of phase 3 of this clinical trial is to compare AMT-116 to stu

Trial Details

NCT ID
NCT07718737
Phase
PHASE2 / PHASE3
Sponsor
Multitude Therapeutics Inc.
Status
RECRUITING
Cancer Type
Lung Cancer
Interventions
  • AMT-116
  • Investigator's choice regimens (docetaxel or docetaxel plus ramucirumab)
Locations (sample)
  • Port Saint Lucie, Florida, United States|27.29393,-80.35033
  • Kingwood, Texas, United States|30.05691,-95.18349
  • Coffs Harbour, Australia|-30.29626,153.11351
  • Melbourne, Australia|-37.814,144.96332
  • Melbourne, Australia|-37.814,144.96332

Key Eligibility Criteria

  • Voluntarily agree to join this clinical trial, sign the informed consent form, and follow all trial arrangements, including scheduled hospital visi…
  • Age between 18 and 80 years old (including 18 and 80 years old) at the time of signing the informed consent form.
  • Diagnosed with non-squamous non-small cell lung cancer (NSCLC) confirmed by pathological or cytological tests. The disease must be either locally a…
  • Must have a clear EGFR gene test result before enrollment. Patients with other actionable gene mutations (excluding EGFR mutation) are eligible. Te…

For full eligibility, visit ClinicalTrials.gov.

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