A Phase II Clinical Study of the Efficacy and Safety of Culmerciclib Rechallenge in HR-positive, HER2-negative Breast Cancer Patients With Resistance to First-line Endocrine Therapy.

To evaluate the efficacy and safety of Culmerciclib combined with fulvestrant compared with investigator-selected CDK4/6 inhibitors combined with fulvestrant in patients with HR-positive/HER2-negative breast cancer who have progressed after first-line endocrine therapy

Trial Details

NCT ID

NCT07666555

Phase

PHASE2

Sponsor

Fudan University

Status

RECRUITING

Cancer Type

HER2 Positive Breast Cancer

Interventions

CDK4/6 inhibitor
Culmerciclib
Fulvestrant

Locations (sample)

Shanghai, China|31.22222,121.45806

Key Eligibility Criteria

1\) Female, ≥18 years old; ≤ 75years old 2)ECOG score 0-2; 3) Predicted survival ≥3 months;Patients with locally advanced and/or metastatic breast …

For full eligibility, visit ClinicalTrials.gov.

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