Fluorescence-Guided Surgical Resection for Reducing Unexpected Positive Margins in Patients With Sarcoma, SarcoSIGHT Trial

This phase II trial compares standard of care surgical resection to fluorescence-guided surgical resection using indocyanine green and fluorescence imaging for reducing unexpected positive margin rates in patients with sarcoma. Surgical margins are one of the criteria used in assessing the effectiveness of a given surgical procedure. They are the edges or border of the tissue removed in cancer surgery. A negative margin means that the resected tumor is surrounded by normal tissue, which implies there is no disease left in the patient. By contrast, a positive margin means that sarcoma cells are

Trial Details

NCT ID

NCT07650656

Phase

PHASE2

Sponsor

City of Hope Medical Center

Status

RECRUITING

Cancer Type

Sarcoma

Interventions

Electronic Health Record Review
Fluorescence Imaging
Fluorescence-Guided Surgery
Indocyanine Green
Questionnaire Administration
Resection

Locations (sample)

Duarte, California, United States|34.13945,-117.97729

Key Eligibility Criteria

Documented written informed consent of the participant
Histologically confirmed diagnosis of intermediate to high grade sarcoma
Amenable to surgical resection as a part of curative intent for the patient
Willingness to:

For full eligibility, visit ClinicalTrials.gov.

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