Study of JAB-23E73 in Combination With Chemotherapy in Participants With Metastatic PDAC Harboring KRAS Gene Alterations

The purpose of this study is to determine the safety and efficacy of pan KRAS inhibitor JAB-23E73 in combination with nab-paclitaxel and gemcitabine in participants with metastatic PDAC harboring KRAS gene alterations.

Trial Details

NCT ID
NCT07640295
Phase
PHASE1 / PHASE2
Sponsor
Jacobio Pharmaceuticals Co., Ltd.
Status
RECRUITING
Cancer Type
Pancreatic Ductal Adenocarcinoma Pancreatic Cancer
Interventions
  • JAB-23E73 tablet,nab-paclitaxel,gemcitabine
Locations (sample)
  • Beijing, Beijing Municipality, China|39.9075,116.39723
  • Hangzhou, Zhejiang, China|30.29365,120.16142
  • Beijing, China|39.9075,116.39723
  • Changsha, China|28.19874,112.97087
  • Harbin, China|45.75,126.65

Key Eligibility Criteria

  • Written informed consent signed by the participant or the participant's legally authorized representative must be obtained prior to performing any …
  • 3\. No prior systemic antitumor therapy for advanced disease (treatment-naïve). 4. Presence of KRAS gene alterations: be enrolled upon approval by …
  • 5\. ECOG performance status score of 0 or 1. 6. Adequate organ function.

For full eligibility, visit ClinicalTrials.gov.

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