Testing Short-Course Radiation Versus Standard-Course Radiation for Soft Tissue Sarcomas That Need Surgery and Radiation

This clinical trial compares the effect of short-course ultrahypofractionated radiation therapy over 5 days (UHRT-5) to standard-course radiation therapy over 25 days (RT-25) in treating patients with soft tissue sarcomas of the extremities that may be primary or that may have come back to nearby tissue or lymph nodes after a period of improvement (locally recurrent) and that can be removed by surgery (resectable). Radiation therapy uses high energy x-rays, particles, or radioactive seeds to kill tumor cells and shrink tumors. 3-dimensional (3D) conformal radiation therapy (CRT) uses a compute

Trial Details

NCT ID
NCT07615049
Phase
PHASE3
Sponsor
SWOG Cancer Research Network
Status
RECRUITING
Cancer Type
Sarcoma
Interventions
  • 3-Dimensional Conformal Radiation Therapy
  • Biospecimen Collection
  • Computed Tomography
  • Intensity-Modulated Radiation Therapy
  • Magnetic Resonance Imaging
  • Surgical Procedure
Locations (sample)
  • Birmingham, Alabama, United States|33.52066,-86.80249
  • Anaheim, California, United States|33.83529,-117.9145
  • Antioch, California, United States|38.00492,-121.80579
  • Bellflower, California, United States|33.88168,-118.11701
  • Dublin, California, United States|37.70215,-121.93579

Key Eligibility Criteria

  • Participants must have histological evidence of a soft tissue sarcoma from core or incisional biopsy. Participants must have a primary or locally r…
  • Prior partial excision or partial excisional biopsy of the tumor, with imaging evidence of gross residual disease \> 1cm in longest dimension (stag…
  • Participants must have a primary site of disease in the extremity, including the shoulder girdle and hip girdle but excluding the hands and feet
  • Participants with primary sites of trunk, head, neck, or intra-abdominal, intrapelvic, or retroperitoneal region are not eligible

For full eligibility, visit ClinicalTrials.gov.

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