A Study to Test the Safety, Tolerability and Effect of ZI-MA4-1 for Patients With Locally Advanced or Metastatic Solid Malignancies

This study will recruit patients with the following cancer indications: ovarian cancer, squamous non-small cell lung cancer, synovial sarcoma and head and neck cancer, with inoperable locally advanced or metastatic solid tumours. Currently, these patients have a poor prognosis and a relatively short overall survival. There is a lack of meaningful, effective therapies available that improve the outcome for these patients. The treatment being investigated in this study is ZIMA4-1, an allogeneic cell therapy product. This is the first time ZI-MA4-1 will be administered to humans. The study is pla

Trial Details

NCT ID
NCT07613723
Phase
PHASE1
Sponsor
Zelluna Immunotherapy AS
Status
RECRUITING
Cancer Type
Lung Cancer
Interventions
  • ZI-MA4-1 (TCR-NK cells)
  • Cyclophosphamide
  • Fludarabine
Locations (sample)
  • London, United Kingdom|51.50853,-0.12574
  • Manchester, United Kingdom|53.48095,-2.23743

Key Eligibility Criteria

  • HLA-A\*02:01 positive
  • Tumour(s) show expression of the MAGE-A4 protein above a defined threshold
  • Histopathological or cytological diagnosis of inoperable Locally Advanced or Metastatic malignant disease: ovarian cancer, squamous non-small cell …
  • No approved therapy with demonstrated clinical benefit is indicated or available to treat the patient, or the patient is intolerant of or has refus…

For full eligibility, visit ClinicalTrials.gov.

Check If You May Be Eligible

Trialify translates complex eligibility criteria into plain yes-or-no questions to help you understand if this trial might be right for you.

Find Lung Cancer Trials on Trialify →