Phase Ib/II Platform Study of Multiple Anti-Cancer Agents in Participants With Metastatic Prostate Cancer

The purpose of the study is to evaluate the safety, tolerability, pharmacokinetics (PK), pharmacodynamics, and preliminary efficacy of multiple anti-cancer agents in participants with metastatic prostate cancer.

Trial Details

NCT ID
NCT07590934
Phase
PHASE1 / PHASE2
Sponsor
AstraZeneca
Status
RECRUITING
Cancer Type
Prostate Cancer
Interventions
  • AZD2265 (FPI-2265)
  • Palacaparib (AZD9574)
  • Docetaxel
  • AZD2287 (Imaging agent)
Locations (sample)
  • Duarte, California, United States|34.13945,-117.97729
  • Encino, California, United States|34.15917,-118.50119
  • South Pasadena, California, United States|34.11612,-118.15035
  • Miami, Florida, United States|25.77427,-80.19366
  • Orlando, Florida, United States|28.53834,-81.37924

Key Eligibility Criteria

  • Participants with a diagnosis of histologically confirmed adenocarcinoma of the prostate (no small cell, neuroendocrine, sarcomatoid, spindle or si…
  • Minimum life expectancy of 3 months or more.
  • Eastern Cooperative Oncology Group (ECOG) performance status of O or 1 at screening, with no deterioration.
  • PCWG3 (Prostate Cancer Working Group 3) modified RECIST Version 1.1 evaluable disease.

For full eligibility, visit ClinicalTrials.gov.

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