Proton Versus Photon Therapy in Head and Neck Squamous Cell Carcinomas.

A national, randomized, clinical trial (phase III) investigating radiotherapy with protons compared with photons for patients with squamous cell carcinoma of the head and neck area eligible for radiotherapy, either radical or postoperative, with curative intent. Comparative dose plans with protons and photons will be prepared, and the probability of toxicity evaluated with NTCP models. Patients with presumed benefit from protons will be randomized 1:1 to treatment with protons or photons. The number of randomized participants will be 400. The primary endpoint is "combined toxicity burden" - dr

Trial Details

NCT ID
NCT07580300
Phase
PHASE3
Sponsor
Oslo University Hospital
Status
RECRUITING
Cancer Type
Head and Neck Cancer
Interventions
  • Proton Radiotherapy
Locations (sample)
  • Bergen, Norway|60.39299,5.32415
  • Oslo, Norway|59.91273,10.74609
  • Tromsø, Norway|69.6489,18.95508
  • Trondheim, Norway|63.43049,10.39506

Key Eligibility Criteria

  • Signed informed consent.
  • Age ≥ 40 years.
  • Histological or cytological verified squamous cell carcinoma of the following head and neck regions; oral cavity, oropharynx, hypopharynx or larynx.
  • Planned for standard radiotherapy with curative intent, either as definitive or postoperative treatment with or without concomitant chemotherapy (c…

For full eligibility, visit ClinicalTrials.gov.

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