Symbiotic-GYN-18: A Study to Learn About the Study Medicine Called PF-08634404 in Combination With Chemotherapy in Adult Participants With Advanced or Recurrent MMR-proficient Endometrial Cancer

This study is being conducted to assess whether the study medicine PF 08634404, given in combination with chemotherapy, improves outcomes compared with another medicine called pembrolizumab plus chemotherapy. Chemotherapy is a type of cancer treatment that uses medicines to destroy cancer cells or stop them from growing. Our bodies have a built-in DNA "spell-checker," called the mismatch repair (MMR) system, that fixes genetic mistakes. In most endometrial cancers, this system works normally, and these cancers are called MMR-proficient (pMMR). However, pMMR tumors are harder for the immune sy

Trial Details

NCT ID
NCT07578649
Phase
PHASE3
Sponsor
Pfizer
Status
RECRUITING
Cancer Type
Uterine Cancer
Interventions
  • PF-08634404
  • Pembrolizumab
  • Standard of Care Chemotherapy
Locations (sample)
  • Jupiter, Florida, United States|26.93422,-80.09421
  • Orlando, Florida, United States|28.53834,-81.37924
  • Orlando, Florida, United States|28.53834,-81.37924
  • Orlando, Florida, United States|28.53834,-81.37924
  • Orlando, Florida, United States|28.53834,-81.37924

Key Eligibility Criteria

  • Women ≥18 years of age who are confirmed not pregnant at screening.
  • Histologically or cytologically confirmed endometrial cancer that is recurrent or advanced; carcinosarcomas are eligible but pure sarcomas are excl…
  • Newly diagnosed FIGO Stage III disease with measurable disease per RECIST v1.1, newly diagnosed FIGO Stage IV disease with or without measurable di…
  • For participants with recurrent disease, prior adjuvant systemic anti-cancer therapy is allowed if relapse occurred more than 6 months after the la…

For full eligibility, visit ClinicalTrials.gov.

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