Study to Assess the Efficacy and Safety of Rina-S With or Without Bevacizumab Compared to Investigator's Choice of Platinum-based Chemotherapy With or Without Bevacizumab as Second-line Treatment in Participants With Recurrent Platinum-sensitive Ovarian Cancer

This Phase 3 study will be conducted in different countries around the world with up to about 688 participants. The purpose of this study is to evaluate how well Rina-S works against ovarian cancer in combination with or without bevacizumab and how it compares to an investigator's choice of platinum-based chemotherapy with or without bevacizumab. Participants will receive either: * Rina-S monotherapy (by itself), * Rina-S plus bevacizumab, * investigator's choice chemotherapy (by itself) (standard of care), or * investigator's choice chemotherapy plus bevacizumab (standard of care). No par

Trial Details

NCT ID
NCT07564141
Phase
PHASE3
Sponsor
Genmab
Status
RECRUITING
Cancer Type
Ovarian Cancer
Interventions
  • Rina-S
  • Bevacizumab
  • Carboplatin
  • Gemcitabine
  • Paclitaxel
  • PLD
Locations (sample)
  • Duarte, California, United States|34.13945,-117.97729
  • Danbury, Connecticut, United States|41.39482,-73.45401
  • Tigard, Oregon, United States|45.43123,-122.77149
  • Bensalem, Pennsylvania, United States|40.10455,-74.95128
  • South Jordan, Utah, United States|40.56217,-111.92966

Key Eligibility Criteria

  • Participant must have histologically confirmed high-grade serous or endometrioid epithelial ovarian cancer (EOC), including primary peritoneal or f…
  • Participant must have documented recurrence or progression after first-line (1L) platinum-based chemotherapy regimen (carboplatin + paclitaxel ≥ 4 …
  • Prior poly (ADP-ribose) polymerase inhibitor(s) (PARPi) maintenance therapy (alone or in combination with bevacizumab) is required for participants…
  • Participants must have measurable disease per RECIST v1.1 by investigator at baseline.

For full eligibility, visit ClinicalTrials.gov.

Check If You May Be Eligible

Trialify translates complex eligibility criteria into plain yes-or-no questions to help you understand if this trial might be right for you.

Find Ovarian Cancer Trials on Trialify →