Endoscopic Ultrasound-Guided Chemoablation for the Treatment of Pancreatic Cystic Neoplasms

This phase II trial tests the effect of endoscopic ultrasound (EUS)-guided chemoablation in treating patients with pancreatic cysts. Pancreatic cancer is a fatal disease that is difficult to diagnose at an early stage, and the five-year survival rate is currently less than 10%. Pancreatic cysts are a common precancerous lesion that may develop into pancreatic cancer. An EUS is a procedure in which an endoscope is inserted into the body. An endoscope is a thin, tube-like instrument that has a light and a lens for viewing. A probe at the end of the endoscope is used to bounce high-energy sound w

Trial Details

NCT ID
NCT07529483
Phase
PHASE2
Sponsor
Ohio State University Comprehensive Cancer Center
Status
RECRUITING
Cancer Type
Pancreatic Cancer
Interventions
  • Ablation Therapy
  • Biospecimen Collection
  • Computed Tomography
  • Electronic Health Record Review
  • Endoscopic Ultrasound
  • Endoscopic Ultrasound-Guided Fine-Needle Aspiration
Locations (sample)
  • Columbus, Ohio, United States|39.96118,-82.99879

Key Eligibility Criteria

  • Age \> 18 years
  • A diagnosis of a pancreatic cystic neoplasm (PCN) confirmed by endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) including cyst fluid n…
  • The pancreatic cystic lesion (PCL) measures at least 1 cm in diameter on CT, MRI/MRCP, or EUS
  • This cohort may include patients with PCNs previously treated with other ablative modalities include EUS-radiofrequency ablation (RFA) (NCT05961982…

For full eligibility, visit ClinicalTrials.gov.

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