Integration of Adaptive Proton Therapy in Pediatric Solid Tumors and Hodgkin's Lymphoma

Pediatric patients receiving proton therapy for solid tumors or Hodgkin's lymphoma may experience anatomical changes during treatment that can affect proton therapy accuracy. This prospective single-arm study uses regular low-dose imaging to monitor these changes and adjust treatment plans as needed. Participants will receive weekly or every-other-week CT scans, with MRI when appropriate, to assess whether the original plan remains accurate. Treatment plans will be updated if tumor coverage decreases by more than 5% or if radiation dose to normal tissues increases by more than 10%; otherwise,

Trial Details

NCT ID
NCT07514819
Phase
NA
Sponsor
St. Jude Children's Research Hospital
Status
RECRUITING
Cancer Type
Sarcoma
Interventions
  • Proton Therapy (Adaptive)
Locations (sample)
  • Memphis, Tennessee, United States|35.14953,-90.04898

Key Eligibility Criteria

  • Participants diagnosed with solid tumors, including Rhabdomyosarcoma, Osteosarcoma, Ewing sarcoma, other sarcomas and carcinomas or also Hodgkin's …
  • Participants who receive proton radiation therapy at St. Jude Children's Research Hospital.
  • Research participant or legal guardian/representative gives written informed consent.

For full eligibility, visit ClinicalTrials.gov.

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