Sacituzumab Govitecan With Bevacizumab Compared to Usual Chemotherapy (Carboplatin, Pegylated Liposomal Doxorubicin and Bevacizumab) for Treating Recurrent Platinum-Sensitive Ovarian Cancer After PARP Inhibitor Maintenance Therapy

This phase II trial compares the effect of sacituzumab govitecan and bevacizumab to standard care (carboplatin, pegylated liposomal doxorubicin, and bevacizumab) in patients with ovarian cancer that has come back after an initial response to platinum therapy (platinum-sensitive), that has progressed after poly (adenosine diphosphate-ribose) polymerase (PARP) inhibitor maintenance therapy (recurrent), and that has a mutation in the BRCA1 or BRCA2 genes or is homologous recombination deficient. Sacituzumab govitecan is a monoclonal antibody, called sacituzumab, linked to a drug called govitecan.

Trial Details

NCT ID
NCT07504588
Phase
PHASE2
Sponsor
National Cancer Institute (NCI)
Status
RECRUITING
Cancer Type
Ovarian Cancer
Interventions
  • Anti-VEGF Monoclonal Antibody
  • Bevacizumab
  • Biospecimen Collection
  • Carboplatin
  • Computed Tomography
  • Echocardiography Test
Locations (sample)
  • Fayetteville, Arkansas, United States|36.06258,-94.15743
  • Rogers, Arkansas, United States|36.33202,-94.11854
  • Springdale, Arkansas, United States|36.18674,-94.12881
  • Coeur d'Alene, Idaho, United States|47.67768,-116.78047
  • Post Falls, Idaho, United States|47.71796,-116.95159

Key Eligibility Criteria

  • Patients must have histologic diagnosis of high grade serous or endometrioid epithelial ovarian cancer
  • Ovarian cancer = fallopian tube, ovarian, and primary peritoneal cancer
  • Disease must be platinum sensitive, as defined by progression documented ≥ 6 months (182 days) from the last receipt of platinum
  • Disease must have progressed during first line maintenance PARP inhibitor (PARPi) for advanced ovarian cancer. NO intervening therapies between pro…

For full eligibility, visit ClinicalTrials.gov.

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