Ozone Therapy With Biomimetic Oral Care for Cancer-Related Oral Mucositis

Oral mucositis is a frequent and often debilitating complication of radiotherapy and chemotherapy, particularly in patients treated for head and neck cancers. It is characterized by inflammation and ulceration of the oral mucosa, leading to pain, difficulty swallowing, taste disturbances, dry mouth, and impairment of daily activities. In more severe cases, oral mucositis may require modification or temporary interruption of cancer treatment. This randomized controlled clinical trial is designed to assess the clinical effectiveness of gas ozone therapy in patients with radio- and chemotherapy-

Trial Details

NCT ID
NCT07491536
Phase
NA
Sponsor
University of Pavia
Status
RECRUITING
Cancer Type
Salivary Gland Head and Neck Cancer
Interventions
  • Gas Ozone Therapy
  • Biomimetic Oral Care Regimen
Locations (sample)
  • Pavia, Lombardy, Italy|45.19205,9.15917

Key Eligibility Criteria

  • Age ≥ 18 years
  • Confirmed diagnosis of radio- and/or chemotherapy-induced oral mucositis, grade 1-3 according to the WHO Oral Toxicity Scale
  • Undergoing oncologic treatment for solid malignancies, particularly head and neck cancers
  • Clinically stable general health condition (ASA physical status I-III)

For full eligibility, visit ClinicalTrials.gov.

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