Non-inferiority Study Comparing Salvage Pelvic Radiotherapy in 25 Fractions (62.5 Gy/25) Versus 20 Fractions (52.5 Gy/20) for Recurrent Prostate Cancer After Surgery.

Study Overview This research compares two types of post-operative salvage radiotherapy (SRT) for men with prostate cancer who have had surgery but show signs of recurrence (detectable PSA). The goal is to see if a shorter treatment schedule is as safe and effective as the standard schedule. Why is this study important? After prostate surgery, cancer can return in up to 70-80% of high-risk patients. Radiotherapy helps control this, but the best way to deliver it-especially the number of sessions and whether to treat the pelvic area-is still being studied. Shorter treatments could mean less tim

Trial Details

NCT ID
NCT07483658
Phase
NA
Sponsor
CHU de Quebec-Universite Laval
Status
RECRUITING
Cancer Type
Prostate Cancer
Interventions
  • Standard Fractionation Post-Operative Salvage Radiotherapy (25 fractions)
  • Hypofractionated Post-Operative Salvage Radiotherapy (20 fractions)
  • Androgen Deprivation Therapy (ADT)
Locations (sample)
  • Gatineau, Quebec, Canada|45.47723,-75.70164
  • Montreal, Quebec, Canada|45.50884,-73.58781
  • Montreal, Quebec, Canada|45.50884,-73.58781
  • Québec, Quebec, Canada|46.81228,-71.21454

Key Eligibility Criteria

  • Histologically confirmed prostate adenocarcinoma.
  • Prior radical prostatectomy with detectable PSA (≥0.2 ng/mL).
  • No evidence of distant metastasis (confirmed via bone scan and CT/MRI or TEP-PSMA if PSA is above 0.5 ng /ml).
  • Patient with Nodal recurrence within the pelvis are eligible

For full eligibility, visit ClinicalTrials.gov.

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