A Study of the Impact of Endocrine Therapy on Surgical Outcomes in People With Breast Cancer

The purpose of this study is to look at how effective neoadjuvant (before surgery) endocrine therapy (NET) is in participants with invasive lobular carcinoma (ILC) who have breast-conserving surgery (BCS). The main purpose of the study is to see if NET reduces the chance of having cancer cells at the edges of tissue removed during surgery (positive margins).

Trial Details

NCT ID
NCT07483307
Phase
PHASE2
Sponsor
Memorial Sloan Kettering Cancer Center
Status
RECRUITING
Cancer Type
Lobular Carcinoma Breast Cancer
Interventions
  • Neoadjuvant endocrine therapy
Locations (sample)
  • Basking Ridge, New Jersey, United States|40.70621,-74.54932
  • Middletown, New Jersey, United States|40.39428,-74.11709
  • Montvale, New Jersey, United States|41.04676,-74.02292
  • Commack, New York, United States|40.84288,-73.29289
  • Harrison, New York, United States|40.96899,-73.71263

Key Eligibility Criteria

  • Written informed consent by participant or legally authorized representative
  • Postmenopausal women aged ≥50 years with biopsy-proven cT2-T3 N0-1 ILC who opt to undergo and are medically fit to undergo BCS at enrollment.
  • Tumors of the ER+/HER2- subtype, defined as:
  • ER+: Positive for ER staining as indicated by ≥10% immunoreactive tumor nuclei.

For full eligibility, visit ClinicalTrials.gov.

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