Glofitamab Combined With Lenalidomide in High Risk Patients With Relapsed or Refractory Mantle Cell Lymphoma

A single-arm, open-label, multi-center clinical study of glofitamab combined with lenalidomide in high risk patients with relapsed or refractory Mantle Cell Lymphoma previously treated with a BTK Inhibitor. Patients will be eligible if they have received one or more prior lines of therapy, one of which must have been a BTKi. Patients will be enrolled according to a Simon two-stage design, with early stop criteria for lack of efficacy. Glofitamab will be administered intravenously and lenalidomide will be self-administered orally. Obinutuzumab pretreatment will be administered intravenously

Trial Details

NCT ID
NCT07460362
Phase
PHASE2
Sponsor
Peking University Third Hospital
Status
RECRUITING
Cancer Type
Lymphoma
Interventions
  • Glofitamab
  • Lenalidomide
Locations (sample)
  • Beijing, Beijing Municipality, China|39.9075,116.39723

Key Eligibility Criteria

  • • Signed Informed Consent Forms
  • Age: \>= 18 to 80 years
  • Eastern Cooperative Oncology Group =\< 2
  • Diagnosis of MCL established by histologic assessment

For full eligibility, visit ClinicalTrials.gov.

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