Pre-Radiation Chemotherapy for Newly Diagnosed High-Grade Glioma.

Better treatments are needed for high-grade gliomas (HGG), and new ways of treating this disease should be tested. The investigators want to see if giving medicine before radiation works well. After radiation, MRI scans can be harder to understand because radiation changes how the brain looks on the scan. If new medicines are given before radiation, the scans are easier to read. First, the investigators need to find out if giving chemotherapy early works using a drug we already know can treat gliomas. The investigators will start with temozolomide, which is the only chemotherapy approved by t

Trial Details

NCT ID
NCT07439172
Phase
PHASE2
Sponsor
The Cooper Health System
Status
RECRUITING
Cancer Type
Glioblastoma (GBM) Brain Cancer
Interventions
  • Pre-radiation temozolomide.
Locations (sample)
  • Camden, New Jersey, United States|39.92595,-75.11962

Key Eligibility Criteria

  • Pathologic diagnosis of high-grade glioma
  • Residual measurable post-operative contrast enhancing tumor
  • Lack of urgency in requiring immediate radiation or chemotherapy (mass effect, mid-line shift, herniation, etc.)
  • Ability to provide informed consent

For full eligibility, visit ClinicalTrials.gov.

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