Electrochemotherapy-Induced Changes in Tumor Microenvironment in Cutaneous Melanoma

Cutaneous melanoma frequently develops cutaneous and subcutaneous metastases, which may cause significant morbidity and negatively affect quality of life. Electrochemotherapy (ECT) is an established local treatment modality for cutaneous and subcutaneous tumor lesions that combines the administration of cytotoxic drugs with the application of electric pulses to increase drug uptake into tumor cells. In addition to its direct cytotoxic effects, electrochemotherapy may induce changes in the tumor microenvironment, including immune cell infiltration, vascular alterations, and other biological re

Trial Details

NCT ID
NCT07404605
Phase
NA
Sponsor
Institute of Oncology Ljubljana
Status
RECRUITING
Cancer Type
Melanoma
Interventions
  • Electrochemotherapy
Locations (sample)
  • Ljubljana, Slovenia|46.05108,14.50513

Key Eligibility Criteria

  • Adults aged 18 years or older
  • Histologically confirmed cutaneous melanoma
  • Presence of cutaneous and/or subcutaneous metastases eligible for electrochemotherapy
  • Candidate for electrochemotherapy with intravenous bleomycin or intratumoral cisplatin according to standard clinical practice

For full eligibility, visit ClinicalTrials.gov.

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