KETO-TUMOR: a Study on Brain Tumors and Central Obesity

Hypothalamic-chiasmatic tumours account for 5-10% of CNS tumours in children and can compromise hypothalamic function, causing alterations in energy balance and weight gain. In inoperable cases, chemotherapy and radiotherapy are used; the latter, although the gold standard, is associated with significant neurocognitive and endocrine-metabolic side effects, proportional to the hypothalamic damage. The ketogenic diet, used for decades in the treatment of drug-resistant childhood epilepsy, induces the use of ketone bodies as a source of energy for the brain and is effective in controlling seizur

Trial Details

NCT ID
NCT07396896
Phase
NA
Sponsor
Meyer Children's Hospital IRCCS
Status
RECRUITING
Cancer Type
Brain Cancer
Interventions
  • Dietary intervention
Locations (sample)
  • Florence, Florence, Italy|43.77925,11.24626

Key Eligibility Criteria

  • Diagnosis of hypothalamic-chiasmatic tumour according to the WHO 2021 classification
  • Diagnosis of hypothalamic obesity: after 5 years of age, BMI \>97th percentile in the WHO 2007 curves
  • Males and females aged between 7 and 30 years
  • Performance status: Lansky score \> 40 for patients aged \< 18 years and Karnofsky score \> 40 for patients aged between 18 and 30 years

For full eligibility, visit ClinicalTrials.gov.

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