Androgen-responsive POSLUMA-guided Intra-prostatic Boost

This research study is for men with intermediate- or high-risk prostate cancer who are planning to receive hormone therapy and radiation treatment. The purpose of the study is to see whether a special type of diagnostic imaging done during hormone therapy can help doctors more accurately target remaining cancer with radiation, while avoiding areas that may no longer need extra treatment. All participants will receive standard hormone therapy and radiation therapy, along with three imaging scans, over a six-month period. The information gained from this study may help make prostate cancer radia

Trial Details

NCT ID
NCT07393867
Phase
PHASE2
Sponsor
Martin T. King, MD, PhD
Status
RECRUITING
Cancer Type
Prostate Cancer
Interventions
  • PSMA PET/CT
  • Androgen Deprivation Therapy (ADT) +/- bicalutamide
  • Stereotactic Body Radiation Therapy (SBRT) +/- focal microboost
Locations (sample)
  • Boston, Massachusetts, United States|42.35843,-71.05977
  • Boston, Massachusetts, United States|42.35843,-71.05977
  • Milford, Massachusetts, United States|42.13982,-71.51617
  • Weymouth, Massachusetts, United States|42.22093,-70.93977

Key Eligibility Criteria

  • 18 years of age and older.
  • Eastern Oncology Group Status 0 to 1.
  • Histologic diagnosis of prostate cancer.
  • Prior screening MRI with at least one PI-RADS4 or PI-RADS 5 lesion, obtained within 180 days of screening.

For full eligibility, visit ClinicalTrials.gov.

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