Treatment for Advanced Non-small Cell Lung Cancer With Actionable Genomic Alterations After Targeted Treatment and Chemotherapy (An Expanded Lung-MAP Treatment Trial)

This phase II Expanded Lung-MAP treatment trial compares how well sacituzumab govitecan alone, ivonescimab alone, or sacituzumab govitecan in combination with ivonescimab works in treating patients with non-small cell lung cancer (NSCLC) that has come back after a period of improvement (recurrent) or is stage IV and has a change in at least 1 of these genes: ALK, EGFR, HER2 (ERBB2), MET, NTRK, RET, and ROS1. This type of gene change is called an actionable genomic alteration (AGA), which means certain treatments can target the change to fight the cancer. Sacituzumab govitecan is a monoclonal a

Trial Details

NCT ID
NCT07393555
Phase
PHASE2
Sponsor
SWOG Cancer Research Network
Status
RECRUITING
Cancer Type
Non-Small Cell (NSCLC) Lung Cancer
Interventions
  • Biospecimen Collection
  • Computed Tomography
  • Ivonescimab
  • Magnetic Resonance Imaging
  • Sacituzumab Govitecan
Locations (sample)
  • Berkeley, California, United States|37.87159,-122.27275
  • Palo Alto, California, United States|37.44188,-122.14302
  • Sacramento, California, United States|38.58157,-121.4944
  • Gainesville, Georgia, United States|34.29788,-83.82407
  • Coeur d'Alene, Idaho, United States|47.67768,-116.78047

Key Eligibility Criteria

  • Participants must have been assigned to S1900N by the Southwest Oncology Group (SWOG) Statistics and Data Management Center (SDMC). Assignment to S…
  • Participants must have measurable disease documented by CT or MRI. The CT from a combined positron emission tomography (PET)/CT may be used to docu…
  • Participants must have a CT or MRI scan of the brain to evaluate for CNS disease within 42 days prior to randomization.
  • Participants with spinal cord compression or brain metastases must not have residual neurological dysfunction, unless no further recovery is expect…

For full eligibility, visit ClinicalTrials.gov.

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