Modulated Electro-Hyperthermia in Combination With Multimodal Therapy for Locally Advanced Rectal Cancer

The goal of this clinical trial is to investigate if the addition of modulated electro-hyperthermia (mEHT) improves tumor down-staging and pathological response in adult patients (20 years and above) with locally advanced rectal adenocarcinoma (cT3N0M0 with high risk of recurrence, cT3N1-2M0, or cT4N0-2M0). The main questions it aims to answer are: * Does the addition of mEHT to the Total Neoadjuvant Therapy (TNT) regimen significantly increase the rate of tumor down-staging (ypT and ypN) compared to TNT alone? * Does the combination therapy improve the pathological complete response (pCR) ra

Trial Details

NCT ID

NCT07372300

Phase

PHASE3

Sponsor

Shih-Kai Hung

Status

RECRUITING

Cancer Type

Colorectal Cancer

Interventions

• Hyperthermia

Locations (sample)

• Chiayi City, Dalin Township, Taiwan|23.47917,120.44889

Key Eligibility Criteria

• Age: 20 years and above
• Gender: Not restricted
• Initial pathological diagnosis of adenocarcinoma of the rectum
• Expected survival ≥ six months

For full eligibility, visit ClinicalTrials.gov.

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