A Study of Bemotuzumab Plus Chemotherapy and Anlotinib Induction Followed by Bemotuzumab, Anlotinib and Consolidative Thoracic Radiotherapy in Extensive-Stage Small Cell Lung Cancer

This is a phase II study evaluating a new combination therapy for untreated extensive-stage small cell lung cancer. The treatment involves an initial phase with the drug Bemotuzumab plus standard chemotherapy and anlotinib, followed by a phase combining Bemotuzumab, anlotinib, and chest radiation. The primary objectives are to assess the efficacy of this approach in delaying cancer growth (progression-free survival) and to evaluate its safety in approximately 25 patients.

Trial Details

NCT ID
NCT07358676
Phase
PHASE2
Sponsor
Tianjin Medical University Cancer Institute and Hospital
Status
RECRUITING
Cancer Type
Lung Cancer
Interventions
  • Bemotuzumab + Anlotinib + Chemotherapy + Radiotherapy
Locations (sample)
  • Tianjin, Tianjin Municipality, China|39.14222,117.17667

Key Eligibility Criteria

  • Histologically or cytologically confirmed extensive-stage small cell lung cancer (ES-SCLC) per VALG staging.
  • No prior systemic therapy for ES-SCLC.
  • At least one measurable lesion as defined by RECIST 1.1 criteria.
  • Age 18-75 years.

For full eligibility, visit ClinicalTrials.gov.

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