Ruxolitinib Maintenance Post-Hematopoietic Stem Cell Transplant T-Cell Lymphoma

This phase II trial tests how well ruxolitinib as a maintenance medication works to prevent relapse and graft-versus-host disease (GVHD) for patients who have undergone stem cell transplantation for T-cell lymphoma. GVHD is a common problem that may occur after a blood stem cell transplant. The "graft" is the donor blood cells that patients get during the transplant. The "host" is the person receiving the cells. GVHD is when the donor graft attacks and damages some of the transplant recipient's tissues. Ruxolitinib is a type of drug called a Janus kinase (JAK) inhibitor which works by decreasi

Trial Details

NCT ID
NCT07356245
Phase
PHASE2
Sponsor
Ohio State University Comprehensive Cancer Center
Status
RECRUITING
Cancer Type
Lymphoma
Interventions
  • Ruxolitinib
  • Positron emission tomography-computed tomography
  • Bone Marrow Biopsy
  • Biopsy Procedure
  • Biospecimen Collection
Locations (sample)
  • Columbus, Ohio, United States|39.96118,-82.99879
  • Houston, Texas, United States|29.76328,-95.36327

Key Eligibility Criteria

  • Adult patients with T-cell lymphoma \[PTCL (all subtypes), T-PLL, ATLL, and CTCL (all subtypes)\] in partial or complete remission between day +35 …
  • Eastern Cooperative Oncology Group (ECOG) performance status of 2 or less
  • Adequate hematologic function defined by absolute neutrophil count (ANC) \> 1000/mm3 without granulocyte colony-stimulating factor (G-CSF) for at l…
  • Adequate organ function defined by total Bilirubin \< 1.5 x ULN, alanine aminotransferase (ALT) \</= 3 x ULN, CKD-EPI eGFR ≥ 30 ml/min, SpO2 \> 92%…

For full eligibility, visit ClinicalTrials.gov.

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