Study of RMC-5127 in Patients With Advanced KRAS G12V-Mutant Solid Tumors

The purpose of this study is to evaluate the safety, tolerability, pharmacokinetics (PK), and preliminary antitumor activity of RMC-5127 as a monotherapy and in combination with either daraxonrasib or cetuximab in adults with KRAS G12V-mutant solid tumors.

Trial Details

NCT ID
NCT07349537
Phase
PHASE1
Sponsor
Revolution Medicines, Inc.
Status
RECRUITING
Cancer Type
Pancreatic Cancer
Interventions
  • RMC-5127
  • daraxonrasib
  • cetuximab
Locations (sample)
  • Grand Rapids, Michigan, United States|42.96336,-85.66809
  • Dallas, Texas, United States|32.78306,-96.80667
  • San Antonio, Texas, United States|29.42412,-98.49363
  • San Antonio, Texas, United States|29.42412,-98.49363
  • Fairfax, Virginia, United States|38.84622,-77.30637

Key Eligibility Criteria

  • At least 18 years old and has provided informed consent.
  • Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1.
  • Pathologically documented, locally advanced or metastatic KRAS G12V-mutated solid tumor malignancy.
  • Received and progressed or been intolerant to prior standard therapy (including targeted therapy) appropriate for tumor type and stage.

For full eligibility, visit ClinicalTrials.gov.

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