Intensity Modulated PrOton Therapy in Pediatric BRain Tumors (IMPORT)

Children diagnosed with benign or low-grade brain tumors often require radiation therapy to control their disease. While radiation can be effective, traditional techniques using X-rays (photon-based radiotherapy) expose healthy brain tissue to radiation, potentially leading to long-term side effects like memory loss, learning difficulties, hormone imbalances, hearing problems, and a higher risk of secondary cancers. This study, called the IMPORT Trial, aims to compare two types of radiation therapy-Intensity-Modulated Proton Therapy (IMPT) and Intensity-Modulated Radiation Therapy (IMRT)-to de

Trial Details

NCT ID
NCT07338526
Phase
NA
Sponsor
Tata Memorial Centre
Status
RECRUITING
Cancer Type
Brain Cancer
Interventions
  • Intensity-modulated proton therapy (IMPT)
  • Photon-based intensity-modulated radiation therapy (IMRT).
Locations (sample)
  • Mumbai, Maharashtra, India|19.07283,72.88261

Key Eligibility Criteria

  • Age at irradiation: 6 to 16 years
  • Karnofsky/ Lansky Play Performance Status ≥ 60
  • Diagnosis (histopathological/ radiological) of primary brain tumor with an expected survival of \>5 years (e.g., circumscribed gliomas, low grade g…
  • Planned for focal cranial radiotherapy

For full eligibility, visit ClinicalTrials.gov.

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