Sapylin Versus Dexamethasone Inhalation for CCRT-Induced Oral Mucositis in Nasopharyngeal Carcinoma

Radiation therapy is the main treatment for nasopharyngeal carcinoma (NPC), and standard care for advanced NPC often includes combination chemotherapy and radiation (CCRT). However, many patients experience serious side effects, such as painful mouth sores (Radiation-Induced Oral Mucositis, RTOM). These side effects can be so severe that they lower a patient's ability to adhere to treatment, potentially making the CCRT less effective. Studies have shown that a significant number of patients stop treatment early due to this toxicity. Current clinical guidelines from organizations like MASCC/IS

Trial Details

NCT ID

NCT07327216

Phase

PHASE3

Sponsor

Affiliated Hospital of Guangdong Medical University

Status

RECRUITING

Cancer Type

Nasopharyngeal Head and Neck Cancer

Interventions

Sapylin
Dexamethasone
CCRT with Cisplatin

Locations (sample)

Zhanjiang, Guangdong, China|21.23391,110.38749

Key Eligibility Criteria

Stage III-IVa NPC (AJCC 8th edition) diagnosed via pathology in a tertiary hospital;
No previous radiotherapy, chemotherapy, surgery, immunization, or targeted therapy;
Karnofsky Performance Status score ≥80;
Intact and normal oral mucosa before treatment;

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