Polymer-lipid Particle-delivered CAR1920 mRNA CAR-T Therapy for Relapsed/Refractory B-cell Lymphoma/Leukemia

The purpose of this study is to determine the efficacy and safety of the CAR-T cell immunotherapy utilizing polymer-lipid nanoparticles for delivering CD19/CD20 dual-targeting InViVoCAR1920 mRNA, for the first-line consolidation therapy of relapsed/refractory B-cell lymphoma/leukemia.

Trial Details

NCT ID
NCT07321301
Phase
PHASE2
Sponsor
Daihong Liu
Status
RECRUITING
Cancer Type
Lymphoma
Interventions
  • Polymer-Lipid Nanoparticle-Mediated Delivery of CD19/CD20 Dual-Targeting InViVoCAR1920 mRNA for CAR-T Cell Immunotherapy
Locations (sample)
  • Beijing, Beijing Municipality, China|39.9075,116.39723

Key Eligibility Criteria

  • Has voluntarily given informed consent, signed the informed consent form, and is willing and able to comply with the scheduled visits, study treatm…
  • Patients with relapsed/refractory (R/R) B-cell lymphoma/leukemia confirmed by histopathology, cytogenetics, molecular biology, clinical judgment, m…
  • Must meet the following criteria for R/R B-cell malignant tumors:
  • (1) B-cell tumors include 3 categories:

For full eligibility, visit ClinicalTrials.gov.

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