Disitamab Vedotin Combined With Platinum and Bevacizumab as First-Line and Maintenance Therapy for HER2-Expressing, HRD-Negative High-Risk Ovarian Cancer: A Multicenter, Non-Randomized, Single-Arm Phase II Clinical Study

This is a prospective, multicenter, phase II study designed to evaluate the efficacy and safety of disitamab vedotin combined with platinum plus bevacizumab as first-line therapy for HER2-expressing, HRD-negative high-risk ovarian cancer. Forty-three patients with pathologically confirmed HRD-negative high-risk ovarian cancer will be enrolled. After enrollment, patients will receive disitamab vedotin plus platinum and bevacizumab as first-line and maintenance treatment. First-line phase: Carboplatin AUC 5 intravenously on Day 1 every 21 days over 1 h ,Bevacizumab 7.5-15 mg/kg intravenously o

Trial Details

NCT ID

NCT07311577

Phase

PHASE2

Sponsor

Jiangsu Cancer Institute & Hospital

Status

RECRUITING

Cancer Type

Ovarian Cancer

Interventions

• RC48+Carboplatin+Bevacizumab

Locations (sample)

• Nanjing, Jiangsu, China|32.06167,118.77778
• Nanjing, Jiangsu, China|32.06167,118.77778

Key Eligibility Criteria

• Voluntary participation with written informed consent.
• Age 18-75 years.
• Expected survival ≥ 12 weeks.
• Histologically/cytologically confirmed advanced ovarian carcinoma (FIGO Stage III-IV).

For full eligibility, visit ClinicalTrials.gov.

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