Furmonertinib Combined With Intrathecal Chemotherapy and Stereotactic Radiotherapy (SRT) for EGFR-Mutated NSCLC Patients With Brain Parenchymal and Leptomeningeal Metastases

A Single-Arm Clinical Study of Furmonertinib (160mg) Combined with Intrathecal Chemotherapy (ITC) and Stereotactic Radiotherapy (SRT) as First-Line Treatment in EGFR Classic Mutation-Positive NSCLC Patients with Brain Parenchymal and Leptomeningeal Metastases

Trial Details

NCT ID
NCT07304739
Phase
PHASE2
Sponsor
Tianjin Medical University Cancer Institute and Hospital
Status
RECRUITING
Cancer Type
Lung Cancer
Interventions
  • Furmonertinib
  • Intrathecal chemotherapy
  • Stereotactic radiotherapy
Locations (sample)
  • Cangzhou, Hebei, China|38.31124,116.85334
  • Tianjin, Tianjin Municipality, China|39.14222,117.17667
  • Tianjin, Tianjin Municipality, China|39.14222,117.17667

Key Eligibility Criteria

  • 18 to 75 years old, male or female;
  • Histopathologically confirmed, unresectable, and not amenable to curative radiotherapy treatment-naïve locally advanced or metastatic lung adenocar…
  • The patient was confirmed by a local laboratory to have one of the following EGFR mutations :19Del or L858R;
  • The patient has not received any systemic anti-tumor treatment in the locally advanced (the researcher judged that it was not suitable for surgery …

For full eligibility, visit ClinicalTrials.gov.

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