Individualized Neck Cervical Irradiation Prophylaxis Trial of NPC

Based on the pattern of nasopharyngeal carcinoma cervical lymph node metastasis, which typically follows a sequential downward spread with rare skip metastases and a tendency for ipsilateral neck involvement, and in accordance with the latest international guidelines, we propose the following scientific hypothesis: individualized neck prophylactic irradiation for nasopharyngeal carcinoma based on the superior-to-inferior extent of metastatic lymph nodes is feasible. Specifically: if there is no lymph node metastasis, irradiation need only extend to the lower border of Level II; if there are su

Trial Details

NCT ID
NCT07303023
Phase
PHASE3
Sponsor
Fudan University
Status
RECRUITING
Cancer Type
Nasopharyngeal Head and Neck Cancer
Interventions
  • Individualized Neck Irradiation
  • Standard Neck Irradiation
Locations (sample)
  • Shanghai, Shanghai Municipality, China|31.22222,121.45806
  • Shanghai, Shanghai Municipality, China|31.22222,121.45806
  • Hangzhou, Zhejiang, China|30.29365,120.16142
  • Chengdu, China|30.66667,104.06667
  • Chongqing, China|29.56026,106.55771

Key Eligibility Criteria

  • Age 18-70 years.
  • Pathologically confirmed WHO type I, II, or III nasopharyngeal carcinoma.
  • Staged as T1-4N0-3 M0, Stage I-III according to the UICC/AJCC 9th edition staging system.
  • Absence of distant metastasis confirmed by systemic FDG PET/CT (or whole-body bone scan plus chest CT and abdominal ultrasound).

For full eligibility, visit ClinicalTrials.gov.

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