The Efficacy of Sequential Treatment With Bevacizumab Combined With Atezolizumab in Advanced Liver Cancer With MASLD

This research plan involves a treatment approach for advanced hepatocellular carcinoma (HCC) in the context of metabolic-associated steatotic liver disease (MASLD). The study aims to compare the efficacy differences between sequential therapy and concurrent therapy using bevacizumab and atezolizumab for advanced HCC in MASLD. The research will focus on evaluating objective response rates, progression-free survival, disease control rates, and overall survival, while utilizing biomarker analysis to elucidate treatment mechanisms. Additionally, the study will examine treatment safety, including t

Trial Details

NCT ID
NCT07285850
Phase
PHASE2 / PHASE3
Sponsor
Eastern Hepatobiliary Surgery Hospital
Status
RECRUITING
Cancer Type
Liver Cancer
Interventions
  • Sequential treatment of bevacizumab combined with atezolizumab (sequential group)
  • Simultaneous treatment of bevacizumab combined with atezolizumab (same period group)
Locations (sample)
  • Shanghai, Shanghai Municipality, China|31.22222,121.45806

Key Eligibility Criteria

  • Age ≥ 18 years old (gender not limited)
  • ECOG performance status of 0-1
  • Preoperative imaging diagnosis of advanced hepatocellular carcinoma (BCLC stage C or D, unsuitable for surgery)
  • Ultrasound or MRI indicating moderate to severe fatty liver (Fibroscan CAP \> 268 dB/m or MR fat score \> 10%)

For full eligibility, visit ClinicalTrials.gov.

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