A Study of IDE892 as Monotherapy and Combination in MTAP-deleted Advanced Solid Tumors

This is a multicenter clinical study to evaluate the safety, efficacy, and Pharmacokinetics (PK) of IDE892 as monotherapy and in combination with other agents including IDE397 in participants with methylthioadenosine phosphorylase (MTAP)-deleted advanced solid tumors within indications of interest.

Trial Details

NCT ID
NCT07277413
Phase
PHASE1
Sponsor
IDEAYA Biosciences
Status
RECRUITING
Cancer Type
Adenocarcinoma Lung Cancer
Interventions
  • IDE892
  • IDE397
Locations (sample)
  • Santa Rosa, California, United States|38.44047,-122.71443
  • Orlando, Florida, United States|28.53834,-81.37924
  • Omaha, Nebraska, United States|41.25626,-95.94043
  • East Brunswick, New Jersey, United States|40.42788,-74.41598
  • New York, New York, United States|40.71427,-74.00597

Key Eligibility Criteria

  • Are ≥ 18 years of age (or the minimum age of consent in accordance with local regulations) at the time of signing the ICF.
  • Have a histologically confirmed diagnosis of a locally advanced recurrent or metastatic solid tumor type of interest with MTAP deletion (for dose e…
  • Are willing and able to provide blood/tumor tissue samples for biomarker testing. An archival tumor tissue specimen must be provided for central co…
  • Must be willing and able to provide the blood/serum/plasma samples

For full eligibility, visit ClinicalTrials.gov.

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