Assessment of Topical Minoxidil on Intraoperative Flap Perfusion and Cutaneous Flap Viability in Breast Recon

The purpose of the study is to determine whether pharmacologic delay using minoxidil in patients undergoing bilateral risk reducing mastectomy with reconstruction could achieve improvement in flap perfusion and flap viability at the time of surgery. Patients will undergo randomization of their breasts to determine which breast will receive the experimental intervention and which breast will serve as the internal control (receive placebo). The experimental breast will receive the novel pharmacologic delay treatment, 5% minoxidil, while the internal control breast will receive the current standa

Trial Details

NCT ID
NCT07264790
Phase
PHASE1
Sponsor
Duke University
Status
RECRUITING
Cancer Type
Breast Cancer
Interventions
  • Minoxidil
  • Hair mousse
Locations (sample)
  • Durham, North Carolina, United States|35.99403,-78.89862

Key Eligibility Criteria

  • Female sex \> 18 years old
  • Genetic predisposition to cancer
  • Undergoing bilateral prophylactic mastectomy with same-day breast reconstruction
  • Capable of giving informed consent

For full eligibility, visit ClinicalTrials.gov.

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