Liquid Nitrogen Spray Cryotherapy Prior to Neoadjuvant Systemic Therapy in Esophageal Adenocarcinoma

This research study is for people who have locally advanced esophageal adenocarcinoma and are expected to receive chemotherapy. The purpose of this study is to compare the effectiveness of Liquid Nitrogen Spray Cryotherapy (LNSC) in addition to chemotherapy versus chemotherapy alone in the treatment of esophageal adenocarcinoma. LNSC is an FDA approved device that works by using liquid nitrogen to rapidly cool cancerous tissue causing cell damage. Participants in this study will be randomly assigned to either the "LNSC group" or the "No-LNSC group." Participants in the "LNSC group" will underg

Trial Details

NCT ID
NCT07222657
Phase
PHASE2
Sponsor
Case Comprehensive Cancer Center
Status
RECRUITING
Cancer Type
Esophageal Cancer
Interventions
  • Standard of care chemotherapy
  • LNSC
Locations (sample)
  • Weston, Florida, United States|26.10037,-80.39977

Key Eligibility Criteria

  • Adults with locally advanced EAC who are expected to receive FLOT +/-Durvalumab will be eligible to participate.
  • Locally advanced esophageal cancer is defined as TNM stages T1N+M0 or T2-T4aNanyM0, as defined by endoscopic ultrasound (EUS) and PET-CT.

For full eligibility, visit ClinicalTrials.gov.

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