An Investigational Study of BG-75202 Alone and in Combination With Other Therapeutic Agents in Adults With Advanced Solid Tumors

The purpose of this study is to evaluate the safety, tolerability, pharmacokinetics (PK), pharmacodynamics, and preliminary antitumor activity of BG-75202 (KAT6A/B inhibitor) alone and in combination with other therapies in participants with breast cancer and other advanced solid tumors.

Trial Details

NCT ID
NCT07222267
Phase
PHASE1
Sponsor
BeOne Medicines
Status
RECRUITING
Cancer Type
Breast Cancer
Interventions
  • BG-75202
  • CDK4 Inhibitor
  • Estrogen Receptor Antagonist
  • Aromatase Inhibitor
Locations (sample)
  • Birmingham, Alabama, United States|33.52066,-86.80249
  • New Haven, Connecticut, United States|41.30815,-72.92816
  • St Louis, Missouri, United States|38.62727,-90.19789
  • Austin, Texas, United States|30.26715,-97.74306
  • Houston, Texas, United States|29.76328,-95.36327

Key Eligibility Criteria

  • Part 1A: Participants with histologically or cytologically confirmed advanced, metastatic breast cancer and other solid tumors who have exhausted, …
  • Part 1B and Part 2A: Participants with advanced breast cancer with 1 to 3 prior lines of systemic therapy in the metastatic setting. Prior lines in…
  • Parts 2B and 2C: Participants with advanced breast cancer enrolled in regions where cyclin-dependent kinase 4/6 (CDK4/6) inhibitors are not approve…
  • Participants with breast cancer must have histologically or cytologically confirmed advanced breast cancer at the time of most recent testing, base…

For full eligibility, visit ClinicalTrials.gov.

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