177Lu-BetaBart in Patients With Relapsed/Refractory, Locally Advanced Inoperable, or Metastatic Solid Tumors

This is a Phase 1/2a dose escalation and expansion study to determine the safety, tolerability, and preliminary clinical activity of 177LuBetaBart, a lutetium-labeled anti-B7-H3 monoclonal antibody, in patients with relapsed/refractory, locally advanced inoperable, or metastatic solid tumors

Trial Details

NCT ID
NCT07189871
Phase
PHASE1 / PHASE2
Sponsor
Radiopharm Theranostics, Ltd
Status
RECRUITING
Cancer Type
Uterine Cancer
Interventions
  • 177Lu-BetaBart
Locations (sample)
  • Dothan, Alabama, United States|31.22323,-85.39049
  • Grand Rapids, Michigan, United States|42.96336,-85.66809
  • Omaha, Nebraska, United States|41.25626,-95.94043
  • Omaha, Nebraska, United States|41.25626,-95.94043
  • Houston, Texas, United States|29.76328,-95.36327

Key Eligibility Criteria

  • Participants ≥ 18 years of age.
  • Participants with a documented history of histopathologically confirmed CRPC\*, CRC, NSCLC, SCLC, HNSCC, ovarian cancer, cervical cancer, endometri…
  • a. \*Progressive CRPC defined by at least one of the following criteria: i. Two consecutive increases in PSA measured at least 1 week apart. ii. So…
  • iii. Progression of bone disease defined by Prostate Cancer Working Group 3 (PCWG3) as evaluable disease or new bone lesions by bone scan.

For full eligibility, visit ClinicalTrials.gov.

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