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NCT07189871
177Lu-BetaBart in Patients With Relapsed/Refractory, Locally Advanced Inoperable, or Metastatic Solid Tumors
This is a Phase 1/2a dose escalation and expansion study to determine the safety, tolerability, and preliminary clinical activity of 177LuBetaBart, a lutetium-labeled anti-B7-H3 monoclonal antibody, in patients with relapsed/refractory, locally advanced inoperable, or metastatic solid tumors
Trial Details
NCT ID NCT07189871
Phase PHASE1 / PHASE2
Sponsor Radiopharm Theranostics, Ltd
Status RECRUITING
Cancer Type Uterine Cancer
Interventions
Locations (sample) Dothan, Alabama, United States|31.22323,-85.39049 Grand Rapids, Michigan, United States|42.96336,-85.66809 Omaha, Nebraska, United States|41.25626,-95.94043 Omaha, Nebraska, United States|41.25626,-95.94043 Houston, Texas, United States|29.76328,-95.36327
Key Eligibility Criteria
Participants ≥ 18 years of age. Participants with a documented history of histopathologically confirmed CRPC\*, CRC, NSCLC, SCLC, HNSCC, ovarian cancer, cervical cancer, endometri… a. \*Progressive CRPC defined by at least one of the following criteria: i. Two consecutive increases in PSA measured at least 1 week apart. ii. So… iii. Progression of bone disease defined by Prostate Cancer Working Group 3 (PCWG3) as evaluable disease or new bone lesions by bone scan.
For full eligibility, visit ClinicalTrials.gov .
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