Hypofractionated, 3-week, Preoperative Proton or X-ray Radiotherapy for Patients With Localized Soft Tissue Sarcoma

The purpose of the study is to investigate whether a personalized selection of patients with localized soft tissue sarcoma for preoperative proton radiation therapy can reduce long-term radiation side effects without increasing surgical complications or reducing the effectiveness of the treatment. Two radiation plans will be created for each patient-one for protons and one for photons-and through a national meeting, we will determine which type of radiation therapy each patient will receive. The radiation dose will be the same for both photons and protons. The primary endpoint is surgical com

Trial Details

NCT ID
NCT07169344
Phase
PHASE2
Sponsor
Oslo University Hospital
Status
RECRUITING
Cancer Type
Liposarcoma Sarcoma
Interventions
  • preoperative
  • Quality of life
  • Functional outcome
Locations (sample)
  • Bergen, Norway|60.39299,5.32415
  • Oslo, Norway|59.91273,10.74609
  • Tromsø, Norway|69.6489,18.95508
  • Trondheim, Norway|63.43049,10.39506

Key Eligibility Criteria

  • ≥ 18 years of age at the time of informed consent.
  • Histological diagnosis of STS, except rhabdomyosarcoma and Ewing sarcoma. Pleomorphic rhabdomyosarcomas are eligible.
  • Primary tumor localized in head, neck, extremity, girdle and/or trunk wall.
  • Measurable disease according to RECIST v1.1.

For full eligibility, visit ClinicalTrials.gov.

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