T-DXd With or Without Bevacizumab for HER2-low Breast Cancer With Brain Metastasis

A phase II, open-label, multicenter, randomized controlled trial exploring the efficacy and safety of Trastuzumab Deruxtecan combined with or without Bevicizumab in HER2-low breast cancer with brain metastasis.

Trial Details

NCT ID
NCT07150208
Phase
PHASE2
Sponsor
Fudan University
Status
RECRUITING
Cancer Type
Breast Cancer
Interventions
  • Bevacizumab (Bev)
  • Trastuzumab Deruxtecan (T-DXd)
Locations (sample)
  • Shanghai, China|31.22222,121.45806

Key Eligibility Criteria

  • ECOG score of 0 to 1.
  • Expected survival period greater than 12 weeks.
  • Histologically confirmed invasive HER2-low expressing breast cancer (specific definition: breast cancer patients with low expression of human epide…
  • Tumor stage: recurrent or metastatic breast cancer; local recurrence must be confirmed by the researcher to be unable to undergo radical surgical r…

For full eligibility, visit ClinicalTrials.gov.

Check If You May Be Eligible

Trialify translates complex eligibility criteria into plain yes-or-no questions to help you understand if this trial might be right for you.

Find Breast Cancer Trials on Trialify →