Stereotactic Radiation for Growing/Changing Brain Metastases With Same-Day Radiation Planning and Treatment With Margin Reduction

The goal of this study is to evaluate the feasibility and effectiveness of same-day radiation planning and treatment. The study will shorten the time interval between radiation planning (radiation mapping) and radiation treatment. The intent of this shorter time interval is to increase the likelihood that the brain metastases being treated remain fully within the high-dose radiation fields. Participants will be randomized to receive brain-directed stereotactic radiation with a 1mm margin or 0mm margin, have their simulation/radiation planning imaging on the same day that brain-directed stereo

Trial Details

NCT ID
NCT07132190
Phase
PHASE2
Sponsor
Ayal A. Aizer, MD
Status
RECRUITING
Cancer Type
Non-Small Cell (NSCLC) Lung Cancer
Interventions
  • Linear accelerator-based stereotactic radiation for brain metastases using 0mm or 1mm PTV
Locations (sample)
  • Boston, Massachusetts, United States|42.35843,-71.05977

Key Eligibility Criteria

  • Participants must have a biopsy proven solid malignancy with at least one intact, residual or recurrent, intracranial lesion radiographically consi…
  • Growth of 1.0mm per week or more, on average, based on the two most recent brain MRIs preceding study enrollment
  • Abutment, to within 1.0cm, of a region of intracranial edema
  • Proximity (within 5.0cm) to a surgical cavity created within 30 days of enrollment

For full eligibility, visit ClinicalTrials.gov.

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