A Study of Sasanlimab, Palbociclib and Axitinib in Metastatic Renal Cell Carcinoma

The goal of this research study is to evaluate how well and safely the study drugs sasanlimab, palbociclib, and axitinib work for treatment of participants with advanced clear cell renal cell carcinoma (ccRCC) or translocation renal cell carcinoma (tRCC). The name of the study drugs involved in this research study is: * Sasanlimab (a type of monoclonal antibody) * Palbociclib (a type of kinase inhibitor) * Axitinib (a type of Vascular endothelial growth factor inhibitor)

Trial Details

NCT ID
NCT07123090
Phase
PHASE2
Sponsor
Stephanie Berg
Status
RECRUITING
Cancer Type
Kidney Cancer
Interventions
  • Sasanlimab
  • Palbociclib
  • Axitinib
Locations (sample)
  • Boston, Massachusetts, United States|42.35843,-71.05977
  • Boston, Massachusetts, United States|42.35843,-71.05977

Key Eligibility Criteria

  • Histologically or cytologically confirmed unresectable advanced or metastatic renal cell carcinoma with a clear cell component or translocation ren…
  • a. For tRCC please refer to the following for eligibility definitions:
  • i. TFE3 (Xp11.2) translocation RCC: confirmed by IHC; however, FISH should be utilized if IHC is not optimal (ie, conclusive) or unavailable.
  • ii. TFEB rearranged RCC: confirmed by FISH; TFEB amplified tumors are excluded.

For full eligibility, visit ClinicalTrials.gov.

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