A Clinical Trial Comparing Long-Course Versus Short-Course Radiotherapy Followed by Immunotherapy Combined With Total Neoadjuvant Therapy (TNT) to Long-Course Radiotherapy Followed by TNT in Locally Advanced Rectal Cancer

This study is a national multicenter, prospective randomized, placebo- controlled Phase III clinical trial designed to investigate the potential therapeutic benefit of immunotherapy combined with total neoadjuvant therapy (TNT) and to compare the efficacy of different radiotherapy modalities followed by immunotherapy.

Trial Details

NCT ID

NCT07113275

Phase

PHASE3

Sponsor

Tao Zhang

Status

RECRUITING

Cancer Type

Colorectal Cancer

Interventions

Short-course radiotherapy
Long-course radiotherapy
Capecitabine
Oxaliplatin
HLX10
TME surgery

Locations (sample)

Wuhan, Hubei, China|30.58333,114.26667

Key Eligibility Criteria

Patients or their family members agree to participate in the study and sign the informed consent form;
Age 18-75 years, male or female;
Histologically confirmed Locally Advanced rectal adenocarcinoma;
Immunohistochemistry and/or genetic testing confirmed pMMR/MSS;

For full eligibility, visit ClinicalTrials.gov.

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