Triple Negative Breast Cancer and Celecoxib. Pilot Study

Relapses occur in 20 to 30% of patients with early-stage triple-negative breast cancer (TNBC), which is characterized by the absence of three receptors: the estrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor 2 (HER-2). Radiotherapy (RT) can increase or decrease, depending on the patient, the level of cytokines that promote metastasis development. To help prevent the development of metastasis, the cyclooxygenase-2 (COX-2) inhibitor celecoxib will be administered during RT. This treatment aims to prevent RT-induced cytokine increases and, ultimately, im

Trial Details

NCT ID
NCT07104266
Phase
PHASE2
Sponsor
Université de Sherbrooke
Status
RECRUITING
Cancer Type
Triple Negative (TNBC) Breast Cancer
Interventions
  • Celecoxib (Celebrex)
  • Placebo
Locations (sample)
  • Sherbrooke, Quebec, Canada|45.40008,-71.89908

Key Eligibility Criteria

  • Age: 18 years or older
  • Tumor stage: Early
  • TNBC status confirmed by pathology
  • Regional lymph node N0 to N3

For full eligibility, visit ClinicalTrials.gov.

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