Shortening Adjuvant Photon and Proton Irradiation (SAPPHIRe-II): A 4 Cohort, Randomized, Phase II Multi-center Trial Evaluating Shorter Schedules of Adjuvant Regional Nodal Irradiation Among Women and Men With Node-positive and High-risk Node-negative Invasive Breast Cancer

To learn about the effects of shorter RNI regimens in patients with breast cance who have had a lumpectomy or mastectomy and who are at higher risk for lower risk for the disease returning.

Trial Details

NCT ID
NCT07076485
Phase
PHASE2
Sponsor
M.D. Anderson Cancer Center
Status
RECRUITING
Cancer Type
Breast Cancer
Interventions
  • Ultrahypofractionated Radiation
  • Moderately Hypofractionated Radiation
Locations (sample)
  • Loveland, Colorado, United States|40.39776,-105.07498
  • Jacksonville, Florida, United States|30.33218,-81.65565
  • Voorhees Township, New Jersey, United States|40.4795,-74.49062
  • Houston, Texas, United States|29.76328,-95.36327
  • San Antonio, Texas, United States|29.42412,-98.49363

Key Eligibility Criteria

  • Eligibility Criteria Applicable to All Cohorts
  • Histologically confirmed invasive breast cancer (nodal involvement from presumed invasive breast cancer in the setting of occult breast cancer is s…
  • 1\. Regional nodal irradiation recommended by treating radiation oncologist. 2 Negative final surgical margins. 3 No more than 12 weeks have elapse…
  • Eligibility Criteria for the Low-Risk Lumpectomy Cohort

For full eligibility, visit ClinicalTrials.gov.

Check If You May Be Eligible

Trialify translates complex eligibility criteria into plain yes-or-no questions to help you understand if this trial might be right for you.

Find Breast Cancer Trials on Trialify →