Spatially Fractionated Radiotherapy Combined With Immunotherapy for Advanced Solid Tumors

Lattice radiation therapy (LRT) is a spatially fractionated radiotherapy technique that creates alternating high - and low - dose areas within a tumor to enhance local control and reduce toxicity to surrounding tissues. This study aims to evaluate the effectiveness and safety of combining LRT with immunotherapy in patients with advanced or metastatic solid tumors, through a Phase II clinical trial. Patients will receive specific - dose irradiation using a medical linear accelerator. Within the GTV of the largest tumor, spheres (0.5 - 3 cm in diameter) will be created as high - dose targets (LR

Trial Details

NCT ID
NCT07058948
Phase
PHASE2
Sponsor
Tianjin Medical University Cancer Institute and Hospital
Status
RECRUITING
Cancer Type
Lung Cancer
Interventions
  • lattice radiation therapy
Locations (sample)
  • Beijing, Beijing Municipality, China|39.9075,116.39723
  • Cangzhou, Hebei, China|38.31124,116.85334
  • Tianjin, Tianjin Municipality, China|39.14222,117.17667

Key Eligibility Criteria

  • Signed informed consent.
  • Histologically or cytologically confirmed malignant solid tumor.
  • Advanced solid tumor unsuitable for surgery as determined by a multidisciplinary tumor board or consulting physicians.
  • No available standard therapy or inability to tolerate it, with imaging and clinical assessment showing stable disease (SD) or progressive disease …

For full eligibility, visit ClinicalTrials.gov.

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