Early Versus Late Stopping of Antibiotics in Adults With High-risk Hematological Malignancies/Receiving Cellular Therapies and Fever

Pre-neutropenic fever (PNF) (fever following chemotherapy but before developing low white cells) and neutropenic fever (NF) (fever in the setting of low white cells) are very common after chemotherapy for acute leukemia, bone marrow transplantation or Chimeric Antigen Receptor T-cell (CAR T) therapy. Often, there is no bacterial cause for fever found, and in the setting of a well patient with resolved fever, some studies have shown it to be safe to cease antibiotic therapy which was commenced at the onset of fever. This reduces the overall exposure to antibiotics, which can be beneficial to th

Trial Details

NCT ID
NCT07051525
Phase
NA
Sponsor
Peter MacCallum Cancer Centre, Australia
Status
RECRUITING
Cancer Type
Leukemia
Interventions
  • Early antibiotic cessation alert
Locations (sample)
  • Melbourne, Victoria, Australia|-37.814,144.96332
  • Melbourne, Victoria, Australia|-37.814,144.96332

Key Eligibility Criteria

  • Adult patients ( ≥18 years) who are receiving either:
  • Conditioning chemotherapy for an autologous or allogeneic haematopoietic cell transplant or CAR T cell therapy, OR
  • Induction remission chemotherapy for acute leukaemia,
  • AND develop fever ( ≥38degC) between time of initiation of chemotherapy/conditioning administration and ANC recovery to ≥500 cells/mm3 post the ANC…

For full eligibility, visit ClinicalTrials.gov.

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