The Analgesic Effect of Scalp Nerve Block Using Bupivacaine Liposomes for Postoperative Pain Relief After Craniotomy

After undergoing craniotomy, 60% to 84% of neurosurgery patients experience moderate to severe acute pain, primarily in the first 48 hours. This pain is mostly superficial, affecting the muscles and soft tissues around the skull. Poor pain management can lead to complications such as restlessness, nausea, hypertension, increased intracranial pressure, and prolonged recovery, potentially resulting in chronic headaches. Opioids are commonly used to manage this pain but can cause significant side effects like sedation, nausea, and increased intracranial pressure, which can mask serious condition

Trial Details

NCT ID

NCT07049094

Phase

PHASE4

Sponsor

Zhejiang University

Status

RECRUITING

Cancer Type

Brain Cancer

Interventions

• scalp nerve block with 0.25% hydrochloride bupivacaine and 0.67% bupivacaine liposome solution
• scalp nerve block with 0.50% hydrochloride bupivacaine

Locations (sample)

• Hangzhou, Zhejiang, China|30.29365,120.16142

Key Eligibility Criteria

• Age ≥ 18 years
• Scheduled for elective cranial surgery
• Informed consent from the patient or legal representative

For full eligibility, visit ClinicalTrials.gov.

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